BDBM236257 US9365576, 10
SMILES CNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C
InChI Key InChIKey=NZQSMNSXZCVNDS-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 236257
TargetCellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188](Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 0.900nMT: 2°CAssay Description:Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188](Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 0.116nMT: 2°CAssay Description:Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185](Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 478nMT: 2°CAssay Description:Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...More data for this Ligand-Target Pair