BDBM238274 US9409887, I-5

SMILES COc1cc(NC(C)C)ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F

InChI Key InChIKey=VVIRSVARIBXZHS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 238274   

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM238274(US9409887, I-5)
Affinity DataIC50: <1nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM238274(US9409887, I-5)
Affinity DataIC50:  20nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent