BDBM238374 3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid (1ff)

SMILES CC(C)Sc1sc(C(O)=O)c(Sc2ccsc2)c1C#N

InChI Key InChIKey=OKUYIAIWJWNAMV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 238374   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Saccharomyces cerevisiae (Baker's yeast))
Centre De Recherche De Gif

LigandPNGBDBM238374(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Affinity DataIC50:  350nMpH: 7.5Assay Description:Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase alpha subunit/subunit beta(Trypanosoma brucei brucei)
Centre De Recherche De Gif

LigandPNGBDBM238374(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Affinity DataIC50:  2.60E+4nMAssay Description:Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM238374(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Affinity DataIC50:  3.10E+4nMAssay Description:Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed