BDBM24185 (3-aminopropyl)(methyl)phosphinic acid::3-Apmpa::3-aminopropylphosphinic derivative, 2::CGP35024::CHEMBL112710::SKF-97541

SMILES CP(O)(=O)CCCN

InChI Key InChIKey=NHVRIDDXGZPJTJ-UHFFFAOYSA-N

Data  3 KI  4 IC50  2 EC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 24185   

TargetGamma-aminobutyric acid type B receptor subunit 1(Rattus norvegicus (Rat))
University of Sydney

Curated by PDSP Ki Database
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataKi:  16nMMore data for this Ligand-Target Pair
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataKi:  33nM ΔG°:  -10.1kcal/mole EC50:  41nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3(Homo sapiens (Human))
University of Sydney

Curated by PDSP Ki Database
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataKi:  750nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataEC50:  200nMAssay Description:Inhibition of mammalian Gamma-aminobutyric acid type B receptor (potent agonist)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1(Rattus norvegicus (Rat))
University of Sydney

Curated by PDSP Ki Database
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataIC50:  16nMAssay Description:Inhibition of binding of [3H]-CGP-27,492 to gamma-aminobutyric acid type B receptor of rat cortex.More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataIC50:  1nMAssay Description:In vitro displacement of [3H]-GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataIC50:  0.0160nMAssay Description:Inhibition of [3H]-CGP-27,492 binding to Gamma-aminobutyric acid type B receptor of rat cortexMore data for this Ligand-Target Pair