BDBM242374 US10047093, 8-31::US10392392, Example 8-31::US10875864, EX. 8-31::US9416132, 8-31

SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1

InChI Key InChIKey=XRNVABDYQLHODA-JCNLHEQBSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 242374   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataKi:  5nMAssay Description:Inhibition of PIM1 (unknown origin) up to 120 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataIC50: >3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataIC50:  1nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataIC50: >3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataIC50: >3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataIC50: >3.00E+4nMAssay Description:hERG activity assays representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataIC50:  1nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataIC50:  1nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nri Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM242374(US10047093, 8-31 | US10392392, Example 8-31 | US10...)
Affinity DataIC50:  1nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent