BDBM244119 US9428492, 3::US9428492, 3a::US9428492, 3b

SMILES Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C

InChI Key InChIKey=KTOHNYWHPPXADM-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244119   

LigandPNGBDBM244119(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Affinity DataKi:  0.0600nM ΔG°:  -13.9kcal/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM244119(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Affinity DataKi:  0.110nM ΔG°:  -13.6kcal/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM244119(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Affinity DataKi:  1nM ΔG°:  -12.3kcal/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM244119(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition assay using CYP2C9More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent