BDBM24446 2-pyridone analogue, 18::N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}phenyl)-2-oxo-1-(pyridin-2-yl)-1,2-dihydropyridine-3-carboxamide

SMILES Fc1cc(NC(=O)c2cccn(-c3ccccn3)c2=O)ccc1Oc1ccnc2[nH]ccc12

InChI Key InChIKey=CKDFZTKKHWVVPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24446   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM24446(2-pyridone analogue, 18 | N-(3-fluoro-4-{1H-pyrrol...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM24446(2-pyridone analogue, 18 | N-(3-fluoro-4-{1H-pyrrol...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed using baculovirus expressed GST-Met, and poly(Glu/Tyr) as the substrate. Dose response curves were generated to determine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed