BDBM246608 4-{4-[6-(4-(4-Bromophenyl)-3-cyano-2-imino)-1,2-dihydropyridyl]phenylamino}6,7-dimethoxyquinazoline::HER2/EGFR dual kinase inhibitor, 5e

SMILES COc1cc2ncnc(Nc3ccc(cc3)-c3cc(-c4ccc(Br)cc4)c(C#N)c(=N)[nH]3)c2cc1OC

InChI Key InChIKey=GVOPMIJWESGYMJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 246608   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Msa University

LigandPNGBDBM246608(4-{4-[6-(4-(4-Bromophenyl)-3-cyano-2-imino)-1,2-di...)
Affinity DataIC50:  1.94E+3nMAssay Description:Protein kinase assays were performed at ambient temperature for 20-40 min (depending on the target) in a final volume of 25 μl according to the fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM246608(4-{4-[6-(4-(4-Bromophenyl)-3-cyano-2-imino)-1,2-di...)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Msa University

LigandPNGBDBM246608(4-{4-[6-(4-(4-Bromophenyl)-3-cyano-2-imino)-1,2-di...)
Affinity DataIC50:  1.94E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM246608(4-{4-[6-(4-(4-Bromophenyl)-3-cyano-2-imino)-1,2-di...)
Affinity DataIC50:  1.04E+3nMAssay Description:Protein kinase assays were performed at ambient temperature for 20-40 min (depending on the target) in a final volume of 25 μl according to the fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed