BDBM246868 US10053465, 7::US10065963, Compound 7::US10125150, Example 7::US10336759, # 7::US10479803, Example 7::US10519163, Example 7::US10675284, Example 7::US10875847, Compound INCB39110::US11084822, Example 7::US11130767, # 7::US11136326, Example 7::US11285140, Example 364::US11304949, Compound 1::US11324749, Comp. No. 1::US11406640, Comp. No. 1::US11596632, Comp. No. 1::US20240058343, Compound 1::US9732097, Example 7::US9999619, Example 364::{1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl] piperidin-4- yl}-3-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]azetidin-3- yl}acetonitrile

SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=KTBSXLIQKWEBRB-UHFFFAOYSA-N

Data  62 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 246868   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246868(US10053465, 7 | US10065963, Compound 7 | US1012515...)
Affinity DataIC50: <10nMAssay Description:The compounds in Table A were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analy...More data for this Ligand-Target Pair
In DepthDetails US Patent