BDBM246886 US10053465, 25::US10077277, Example 25::US10125150, Example 25::US10336759, # 25::US10479803, Example 25::US10519163, Example 25::US10675284, Example 25::US11084822, Example 25::US11130767, # 25::US11136326, Example 25::US11304949, Compound 25::US11324749, Comp. No. 25::US11406640, Comp. No. 25::US11596632, Comp. No. 25::US11918581, Compound 25::US11957661, Compound 25::US20240058343, Compound 25::US9732097, Example 25::{trans-5-3-(4-{[4- ({[(2S)-2- hydroxypropyl] amino}methyl)-6- (trifluoromethyl) pyridin-2- yl]oxy}piperidin-1- yl)-1-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]cyclobutyl} acetonitrile

SMILES C[C@H](O)CNCc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F

InChI Key

Data  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 246886   

TargetTyrosine-protein kinase JAK1(Human)
Incyte

US Patent
LigandPNGBDBM246886(US10053465, 25 | US10077277, Example 25 | US101251...)
Affinity DataIC50: <10nMAssay Description:JAK1 inhibitors that can be used for the treatment of cytokine-related diseases or disorders are tested for inhibitory activity of JAK targets accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent