BDBM246894 4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrimidin-1-yl)ethyl]- 5-chloro-2-ethoxy-6- fluorophenyl}pyrrolidin- 2-one::US10053465, 32::US11136326, Example 32d::US9730939, Example 348

SMILES CCOc1c(cc(Cl)c(F)c1C1CNC(=O)C1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=ZQPDJCIXJHUERQ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 246894   

LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50: <10nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50:  125nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50:  125nMAssay Description:In some embodiments, the PI3Kδ inhibitor is selective. By ¿selective¿ is meant that the compound binds to or inhibits a kinase with greater affi...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50:  125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50: <10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50:  125nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50:  125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50:  125nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50: <50nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50: <50nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246894(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50: <10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In DepthDetails US Patent