BDBM246940 (2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(pyridin-3-yl)-2,3-dihydro-1H-inden-2-yl)methanamine::US10053465, 77::US10519163, Example 77::US11136326, Example 77

SMILES NCC1(Cc2ccc(cc2C1)-c1cccnc1)c1cccc(c1)-c1ncnc2[nH]ccc12

InChI Key

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 246940   

TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50: >3.00E+3nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50:  2.00E+3nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50: <500nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50: >3.00E+3nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50: <500nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50: <500nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50: >3.00E+3nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50:  2.00E+3nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246940((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(...)
Affinity DataIC50:  2.00E+3nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent