BDBM247037 (1R,3aR,6S,7R, 7aS)-7-((E)-2-(5- (2-cyanophenyl)- 6- methylpyridin-2- yl)vinyl)-5,5- difluoro-1,6- dimethyl-3- oxooctahydro- isobenzofuran- 3a- carboxamide::US9701669, 4
SMILES C[C@H]1OC(=O)[C@@]2(CC(F)(F)[C@@H](C)[C@H](\C=C\c3ccc(c(C)n3)-c3ccccc3C#N)[C@H]12)C(N)=O
InChI Key InChIKey=BZWUQBGOWKHPIR-YYAHKPHASA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 247037
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 6.00E+4nMpH: 7.4 T: 2°CAssay Description:Drug cardiac arrhythmia is an important safety concern for pharmaceutical development and health regulatory authorities. Blockade of heterologously-e...More data for this Ligand-Target Pair
Affinity DataIC50: 6.92nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair