BDBM247042 1R,3aR,6S, 7R,7aS)-7-((E)-2- (2'-cyano-[3,3'- bipyridin]-6- yl)vinyl)-5,5- difluoro-1,6- dimethyl-3- oxooctahydro- isobenzofuran- 3a-carboxamide::US9701669, 11
SMILES C[C@H]1OC(=O)[C@@]2(CC(F)(F)[C@@H](C)[C@H](\C=C\c3ccc(cn3)-c3cccnc3C#N)[C@H]12)C(N)=O
InChI Key InChIKey=UYZBYUIKPXHJNI-INOSTWGMSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 247042
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 6.00E+4nMpH: 7.4 T: 2°CAssay Description:Drug cardiac arrhythmia is an important safety concern for pharmaceutical development and health regulatory authorities. Blockade of heterologously-e...More data for this Ligand-Target Pair
Affinity DataIC50: 9.68nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair