BDBM247043 1-((1R,3aS,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(5-(3- fluorophenyl) pyridin-2- yl)vinyl)-1,6- dimethyl-3- oxo-octahydro- isobenzofuran- 3a-yl)azetidine- 3-carboxamide::US9701669, 13

SMILES C[C@H]1OC(=O)[C@@]2(CC(F)(F)[C@@H](C)[C@H](\C=C\c3ccc(cn3)-c3cccc(F)c3)[C@H]12)N1CC(C1)C(N)=O

InChI Key InChIKey=WABUHAZRFLHFMQ-KMKRIQIBSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 247043   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247043(1-((1R,3aS,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(5-...)
Affinity DataIC50:  3.00E+3nMpH: 7.4 T: 2°CAssay Description:Drug cardiac arrhythmia is an important safety concern for pharmaceutical development and health regulatory authorities. Blockade of heterologously-e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MARK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247043(1-((1R,3aS,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(5-...)
Affinity DataIC50:  13.9nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent