BDBM247129 3-((6-(4-(3-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dimethylphenoxy)pyrimidin-4-yl)amino)-5-methoxy-N-(2-morpholinoethyl)benzamide::US9701670, 91

SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2cc(Nc3cc(OC)cc(c3)C(=O)NCCN3CCOCC3)ncn2)c(C)c1C)C(C)(C)C

InChI Key InChIKey=MTZANZYELGIMJM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 247129   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM247129(3-((6-(4-(3-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H...)
Affinity DataIC50:  9.60nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM247129(3-((6-(4-(3-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H...)
Affinity DataIC50:  3.52E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM247129(3-((6-(4-(3-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H...)
Affinity DataIC50:  131nMAssay Description:The inhibitory activities of compounds of the invention against Syk enzymes (Invitrogen), are evaluated in a similar fashion to that described herein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM247129(3-((6-(4-(3-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H...)
Affinity DataIC50: <1.30nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent