BDBM248957 US9434725, 188
SMILES O[C@@H]1CNCCN(C1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cnn(CC(F)(F)F)c1
InChI Key InChIKey=QDSYVSQEYVFTTI-MRXNPFEDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 248957
Affinity DataKi: 0.173nM ΔG°: -13.3kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Affinity DataKi: 0.611nM ΔG°: -12.6kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Affinity DataKi: 4.64nM ΔG°: -11.4kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Affinity DataIC50: 418nMAssay Description:BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...More data for this Ligand-Target Pair