BDBM249028 US9434725, 259::US9434725, 271::US9434725, 272

SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)C1CNCCC1(F)F

InChI Key InChIKey=OIZRMKSUYVZCDN-UHFFFAOYSA-N

Data  9 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 249028   

TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  0.0235nM ΔG°:  -14.5kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  0.0250nM ΔG°:  -14.5kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  0.0530nM ΔG°:  -14.0kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  0.0670nM ΔG°:  -13.9kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  0.189nM ΔG°:  -13.3kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  0.210nM ΔG°:  -13.2kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  0.234nM ΔG°:  -13.1kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  0.242nM ΔG°:  -13.1kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataKi:  2.45nM ΔG°:  -11.7kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Mus musculus (Mouse))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataIC50:  194nMAssay Description:BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase pim-1(Mus musculus (Mouse))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249028(US9434725, 259 | US9434725, 271 | US9434725, 272)
Affinity DataIC50:  1.40E+3nMAssay Description:BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB