BDBM251471 US9452998, 20::US9452998, 34

SMILES N[C@H]1[C@H]2CC[C@@H]1CN(C2)c1cccnc1NC(=O)c1nc(cnc1N)-c1nc(ccc1C(F)(F)F)N1CCOCC1

InChI Key InChIKey=QHJQKYAQVKTFLI-VPTLXERWSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 251471   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251471(US9452998, 20 | US9452998, 34)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251471(US9452998, 20 | US9452998, 34)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251471(US9452998, 20 | US9452998, 34)
Affinity DataIC50:  1.00E+4nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251471(US9452998, 20 | US9452998, 34)
Affinity DataIC50:  3.60nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251471(US9452998, 20 | US9452998, 34)
Affinity DataIC50:  3.60nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent