BDBM25152 CHEMBL112446::N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide::ketoamide, 12

SMILES CNC(=O)C(=O)CCCCCCC(=O)Nc1cccc(c1)-c1ccccc1

InChI Key InChIKey=QUTIXALGBQKSDN-UHFFFAOYSA-N

Data  3 IC50  2 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25152   

TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(CHEMBL112446 | N-methyl-2-oxo-N'-(3-phenylphenyl)n...)
Affinity DataIC50:  12nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(CHEMBL112446 | N-methyl-2-oxo-N'-(3-phenylphenyl)n...)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase (HDAC1 and HDAC2)(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM25152(CHEMBL112446 | N-methyl-2-oxo-N'-(3-phenylphenyl)n...)
Affinity DataIC50:  3.70nMAssay Description:Inhibitory activity against mixture of histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2) from nuclear extraction of K562 erythroleukemi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(CHEMBL112446 | N-methyl-2-oxo-N'-(3-phenylphenyl)n...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(CHEMBL112446 | N-methyl-2-oxo-N'-(3-phenylphenyl)n...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed