BDBM255303 US9481682, 52

SMILES CC1(C)OC(=O)N2C[C@@H](CC[C@@H]12)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key InChIKey=FUZSHLVNKZZEKR-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 255303   

TargetTyrosine-protein kinase FRK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 36nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 30nMAssay Description:Inhibition of YES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 15nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 27nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 8nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 69nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 24nMAssay Description:Inhibition of PTK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 79nMAssay Description:Inhibition of LYNB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 13nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 212nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 0.130nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fgr(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 34nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 23nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 350nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 17nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 58nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with anti-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of recombinant full length BTK (unknown origin) expressed in baculovirus infected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-NH2 peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed