BDBM256576 US10435361, Example 75::US9481648, 75::US9790174, Example 75
SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)c3)c3ccccc23)cc(cc1C(=O)NC1COC1)C(C)(C)C
InChI Key InChIKey=PKPIKMRNRASAMG-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 256576
Affinity DataIC50: 123nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...More data for this Ligand-Target Pair
Affinity DataIC50: 97nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Affinity DataIC50: 214nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Affinity DataIC50: 6.03E+3nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Summary of CYP3A4 inhibition studies for various Compound Examples using 0 min preincubation.More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Summary of CYP3A4 inhibition studies for various Compound Examples using 30 min preincubation.More data for this Ligand-Target Pair
Affinity DataIC50: 6.03E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Summary of CYP2C9 inhibition studies for various Compound Examples using 30 min preincubation.More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+3nMAssay Description:Compounds of the invention were tested for inhibition of the human ether a go-go (hERG) channel using IonWorks patch clamp electrophysiology at Essen...More data for this Ligand-Target Pair
Affinity DataIC50: 123nMAssay Description:The following two assay variants can be used for determination of p38 MAPKα inhibition.Method 1The inhibitory activities of test compounds again...More data for this Ligand-Target Pair
Affinity DataIC50: 97nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Affinity DataIC50: 214nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Summary of CYP2C9 inhibition studies for various Compound Examples using 0 min preincubation.More data for this Ligand-Target Pair