BDBM25731 1,3-dicyclohexylurea::CHEMBL1458::US8815951, 1,3-dicyclohexylurea::Urea-based compound, 12

SMILES O=C(NC1CCCCC1)NC1CCCCC1

InChI Key InChIKey=ADFXKUOMJKEIND-UHFFFAOYSA-N

Data  11 IC50

PDB links: 7 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 25731   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  290nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Mus musculus (Mouse))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  90nMAssay Description:The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hype...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase 1(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  160nMAssay Description:The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hype...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  90nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  25nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  160nMAssay Description:Inhibition of microsomal epoxide hydrolase (unknown origin) using 7-(2-(Oxiran-2- yl)ethoxy) Resorufin by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM25731(1,3-dicyclohexylurea | CHEMBL1458 | US8815951, 1,3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed