BDBM25737 12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid::CHEMBL215387::US10383835, Compound 700::Urea-based compound, 18
SMILES OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2
InChI Key InChIKey=XLGSEOAVLVTJDH-UHFFFAOYSA-N
Data 44 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 44 hits for monomerid = 25737
Affinity DataIC50: 1.96E+3nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human sEH using cyano(6-methoxynaphthalen-2-yl)methyl((3-phenyloxiran-2-yl)methyl)carbonate as a substrate assessed as reduction in 6-m...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse recombinant soluble Epoxide hydrolaseMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant soluble Epoxide hydrolaseMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human soluble epoxide hydrolase by spectrometric based assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human soluble epoxide hydrolase by fluorescent based assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse soluble epoxide hydrolase by spectrometric based assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence ...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 1.07E+5nMAssay Description:Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured ...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynapthaldehyde product by...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolaseMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of rat recombinant soluble epoxide hydrolaseMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse recombinant soluble epoxide hydrolaseMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 107nMAssay Description:Inhibition of sEH using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of rat recombinant soluble epoxide hydrolase by fluorescent assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse recombinant soluble epoxide hydrolase by fluorescent assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human sEH by fluorescent assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as subs...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 107nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde ...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human sEHMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of mouse sEHMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 107nMAssay Description:Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Sus scrofa (Pig))
The Regents Of The University Of California
US Patent
The Regents Of The University Of California
US Patent
Affinity DataIC50: 11nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
TargetEpoxide hydrolase 1(Felis catus (Cat) (Felis silvestris catus))
The Regents Of The University Of California
US Patent
The Regents Of The University Of California
US Patent
Affinity DataIC50: 3nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
TargetEpoxide hydrolase 1(Canis lupus familiaris (Dog) (Canis familiaris))
The Regents Of The University Of California
US Patent
The Regents Of The University Of California
US Patent
Affinity DataIC50: 3nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin) using NEPC as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 4.40E+3nMAssay Description:Competitive inhibition of soluble epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Inhibition of human sEH using epoxy flour 7 as substrate measured after 30 mins by cell-based fluorescence assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of human sEH using EnzChek as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured every 30 secs for ...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of sEH (unknown origin) expressed in baculovirus expression system incubated for 1 hrMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
California State University
Curated by ChEMBL
California State University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence methodMore data for this Ligand-Target Pair