BDBM25901 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide::Indaflex::Indapamide::Indapamide (2)::Lozol::Noranat

SMILES CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O

InChI Key InChIKey=NDDAHWYSQHTHNT-UHFFFAOYSA-N

Data  17 KI  6 IC50  42 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 25901   

TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1.00E+4nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  300nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  300nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1.40E+3nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Homo sapiens (Human))
Vilnius University

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  100nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  300nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  300nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Homo sapiens (Human))
Vilnius University

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  100nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  200nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 7 by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Homo sapiens (Human))
Vilnius University

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  200nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 13 by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged carbonic anhydrase 7 (3 to 264 residues) expressed in Escherichia coli BL21 (DE3) assesse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  670nMAssay Description:Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 3(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  2.80E+4nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 3 (4 to 260 residues) expressed in Escherichia coli BL21 (DE3) in pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 1 (3 to 261 residues) expressed in Escherichia coli BL21 (DE3) in pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 3(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  105nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 3 (4 to 260 residues) expressed in Escherichia coli BL21 (DE3) assess...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 12 (1 to 260 residues) expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Homo sapiens (Human))
Vilnius University

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  290nMAssay Description:Binding affinity to recombinant human full length N-terminal His-tagged carbonic anhydrase 13 (1 to 262 residues) expressed in Escherichia coli BL21 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  261nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 1 (3 to 261 residues) expressed in Escherichia coli BL21 (DE3) assess...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  430nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 9 (1 to 260 residues) expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  250nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged carbonic anhydrase 7 (3 to 264 residues) expressed in Escherichia coli BL21 (DE3) in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  59nMAssay Description:Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  0.380nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 14 (20 to 280 residues) expressed in Escherichia coli BL21 (DE3) asse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  530nMAssay Description:Binding affinity to recombinant human full length N-terminal His-tagged carbonic anhydrase 2 (1 to 260 residues) expressed in Escherichia coli BL21 (...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  12nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 12 (1 to 260 residues) expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissoc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  2nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 9 (1 to 260 residues) expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissoci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  0.460nMAssay Description:Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  7nMAssay Description:Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to recombinant human full length N-terminal His-tagged carbonic anhydrase 2 (1 to 260 residues) expressed in Escherichia coli BL21 (...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 6 expressed in Escherichia coli BL21 (DE3) assessed as intrinsic diss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 4 expressed in Escherichia coli BL21 (DE3) assessed as intrinsic diss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  63nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 14 (20 to 280 residues) expressed in Escherichia coli BL21 (DE3) in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  710nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 6 expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  77nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 4 expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Homo sapiens (Human))
Vilnius University

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  4.10nMAssay Description:Binding affinity to recombinant human full length N-terminal His-tagged carbonic anhydrase 13 (1 to 262 residues) expressed in Escherichia coli BL21 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  300nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  250nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  300nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 13(Homo sapiens (Human))
Vilnius University

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  100nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed