BDBM262042 2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dimethylamino)thiazol-4-yl)- 1'H-spiro[cyclopropane-1,4'- [2,7]naphthyridin]-3'(2'H)-one::US10251892, Example 160::US10632126, Example 160::US11173162, Example 160::US9708318, 160

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2csc(n2)N(C)C)c1F

InChI Key InChIKey=LVAHFBADTVPISP-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 262042   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
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LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
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LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
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US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
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US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
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LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
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US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
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US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
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US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent

LigandBDBM262042(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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Copy BDB DOI