BDBM26229 2-Aminopyrimidine analog., 4::4-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile::JMC516547 Compound 2

SMILES CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(cc1)C#N

InChI Key InChIKey=QFKQUMBUFVKQBH-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 26229   

TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)
Affinity DataKi:  35nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)
Affinity DataKi:  35nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)
Affinity DataKi:  245nM ΔG°:  -9.01kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)
Affinity DataKi:  275nM ΔG°:  -8.94kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)
Affinity DataKi:  275nM ΔG°:  -8.94kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)
Affinity DataKi:  1.29E+3nM ΔG°:  -8.03kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed