BDBM264123 3-(3-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin-1-yl)propyl)-1H-indole-5-carbonitrile::US9714232, 36

SMILES O=c1cnccn1-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1

InChI Key InChIKey=RLANJTMXVDVGLS-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264123   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264123(3-(3-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin...)
Affinity DataKi:  3nMpH: 7.4Assay Description:Human HEK-293 cell homogenates (36 μg protein) were incubated at 22° C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264123(3-(3-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin...)
Affinity DataIC50:  1.80nMpH: 7.4Assay Description:The synaptosomes (150 μg) prepared from a rat brain were incubated at 37° C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent