BDBM269344 (R)-2-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)phenyl)-1-((1-(1-hydroxycyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-4,4-dimethyl-1H-imidazol-5(4H)-one ::US10413545, Compound 89::US9718813, Compound 89

SMILES Cn1cnc2cc(ccc12)-c1ccc(C2=NC(C)(C)C(=O)N2C[C@@H]2CCN(C2)C(=O)C2(O)CC2)c(F)c1

InChI Key InChIKey=OJDKAHVHJPTSGJ-QGZVFWFLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269344   

TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269344((R)-2-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-...)
Affinity DataIC50:  60.3nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269344((R)-2-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-...)
Affinity DataIC50:  60.3nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent