BDBM269351 6-(4-(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)-3-methylphenyl)-2-naphthonitrile ::US10413545, Compound 96::US9718813, Compound 96

SMILES Cc1cc(ccc1C1=NC(C)(C)C(=O)N1CC1CN(C1)C(=O)C1CC1)-c1ccc2cc(ccc2c1)C#N

InChI Key InChIKey=QADDMTLRTHTBHI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269351   

TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269351(6-(4-(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)me...)
Affinity DataIC50:  40.7nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269351(6-(4-(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)me...)
Affinity DataIC50:  40.7nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent