BDBM270092 (2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-3-(4-methyl-1H-pyrazol-1-yl)-2-butanesulfonamide, (2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-3-(4-methyl-1H-pyrazol-1-yl)-2-butanesulfonamide, (2S,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-3-(4-methyl-1H-pyrazol-1-yl)-2-butanesulfonamide::US10058550, Example 658.0::US10058550, Example 659.0::US10058550, Example 660.0::US10058550, Example 661.0::US10221162, Example 661.0::US9845310, Example 661.0

SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](C)n2cc(C)cn2)n1-c1c(OC)cccc1OC

InChI Key InChIKey=OJMMCIHTIJPORO-SJORKVTESA-N

Data  12 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 270092   

TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  6.80nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  52nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  16nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  0.220nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  6.80nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  0.220nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  16nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  0.220nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  6.80nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  52nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  16nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM270092((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  52nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent