BDBM270540 N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacetyl) phenylamino)pyrimidin-2- ylamino)-4-methoxyphenyl) acrylamide::US10059688, Example 67::US9783524, Example 67

SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1

InChI Key InChIKey=OKCOQQXHDZUFTL-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 270540   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  17nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  500nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  15nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  19nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  273nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  17.3nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  500nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  15.4nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  18.9nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50:  273nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent