BDBM270544 2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- 1-yl)-3-methoxyphenylamino) pyrimidin-4-ylamino)phenyl)- N,N-dimethyl-2-oxoacetamide::US10059688, Example 118::US9783524, Example 118

SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCC(CC1)N(C)C

InChI Key InChIKey=XYNBROWABUHURG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 270544   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  11nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  158nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  5.13nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  4.92nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  77.6nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  10.8nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  158nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  5.13nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  4.92nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50:  78nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent