BDBM273011 (R)-2-{6-methyl-5-[(morpholin-4-yl)methyl]-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl}pyrrolidine-1-carboxylic acid benzyl ester::US10065972, Example 8

SMILES Cn1c(CN2CCOCC2)nc2sc(nc2c1=O)[C@H]1CCCN1C(=O)OCc1ccccc1

InChI Key InChIKey=VQLPBLOZTCZMBE-QGZVFWFLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273011   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273011((R)-2-{6-methyl-5-[(morpholin-4-yl)methyl]-7-oxo-6...)
Affinity DataIC50:  610nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent