BDBM273057 (R)-2-[6-chloro-5-oxo-7-(propan-2-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl]pyrrolidine-1-carboxylic acid phenyl ester::US10065972, Example 153

SMILES CC(C)c1nc2sc(nn2c(=O)c1Cl)[C@H]1CCCN1C(=O)Oc1ccccc1

InChI Key InChIKey=WKQFKXAXDIGBPQ-CYBMUJFWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273057   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273057((R)-2-[6-chloro-5-oxo-7-(propan-2-yl)-5H-[1,3,4]th...)
Affinity DataIC50:  48nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent