BDBM273179 (R)-N-benzyl-1-(7-ethyl-6-fluoro-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-4,4-difluoropyrrolidine-2-carboxamide::US10065972, Example 650

SMILES CCc1nc2sc(nn2c(=O)c1F)N1CC(F)(F)C[C@@H]1C(=O)NCc1ccccc1

InChI Key InChIKey=CTNKUPOEVAGPMZ-CYBMUJFWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273179   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273179((R)-N-benzyl-1-(7-ethyl-6-fluoro-5-oxo-5H-[1,3,4]t...)
Affinity DataIC50:  2.20E+3nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent