BDBM273230 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridine dihydrochloride::US10071079, Example 4::US10478424, Example 4

SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(C)c1C

InChI Key InChIKey=VUZNXUYFHHEUMC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 273230   

TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273230(6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...)
Affinity DataIC50:  0.300nMT: 2°CAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273230(6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...)
Affinity DataIC50:  0.700nMT: 2°CAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273230(6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...)
Affinity DataIC50:  1.59E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273230(6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...)
Affinity DataIC50:  0.300nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273230(6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...)
Affinity DataIC50:  0.700nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273230(6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...)
Affinity DataIC50:  1.59E+3nMT: 2°CAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent