BDBM274310 1-(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1-methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-3-yl)-3-methylurea::US9550796, Example 111

SMILES CNC(=O)Nc1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C(F)F)n2n1)c1ccc(Cl)cc1

InChI Key InChIKey=RNLAJPMWXHNSOJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 274310   

TargetBromodomain-containing protein 4 [44-477](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274310(1-(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-meth...)
Affinity DataIC50: <11nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274310(1-(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-meth...)
Affinity DataIC50: >3.70E+4nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274310(1-(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-meth...)
Affinity DataIC50:  19nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent