BDBM274335 (R)¿N-(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-3-yl)acetamide::US9550796, Example 136

SMILES CC(=O)Nc1cn(C)c2[C@H](N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1

InChI Key InChIKey=SSELZXGQLGXCDT-HXUWFJFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 274335   

TargetBromodomain-containing protein 4 [44-477](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274335((R)¿N-(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]t...)
Affinity DataIC50:  21nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274335((R)¿N-(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]t...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274335((R)¿N-(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]t...)
Affinity DataIC50:  19nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent