BDBM274962 N-(tert-butyl)-5-(3- (trifluoromethoxy)phenyl)-8-((3- (trifluoromethyl)-1H-pyrazole-5- carboxamido)methyl)-3,4- dihydroisoquinoline-2(1H)-carboxamide::US9877957, Example 2

SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)c1cc(n[nH]1)C(F)(F)F)ccc2-c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=RIKDOOCPSCPDTE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 274962   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274962(N-(tert-butyl)-5-(3- (trifluoromethoxy)phenyl)-8-(...)
Affinity DataIC50:  104nMpH: 7.0 T: 2°CAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent