BDBM275041 N2-(tert-butyl)-N8-(pyrazolo[1,5-a]pyridin-7- ylmethyl)-5-(3-(trifluoromethoxy)phenyl)- 3,4-dihydroisoquinoline-2,8(1H)- dicarboxamide::US9877957, Example 79

SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCc1cccc2ccnn12

InChI Key InChIKey=OAOADSKURIQZDB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275041   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275041(N2-(tert-butyl)-N8-(pyrazolo[1,5-a]pyridin-7- ylme...)
Affinity DataIC50:  149nMpH: 7.0 T: 2°CAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent