BDBM27543 4-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]methyl}-1,2-dihydrophthalazin-1-one::Piperazine analogue, 24

SMILES Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCNCC1

InChI Key InChIKey=MFFUYEOGICAKCK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27543   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM27543(4-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]meth...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of PARP-1 (unknown origin) assessed as incorporation of biotinylated poly ADP-ribose onto histone proteins by colorimetric analysis in pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM27543(4-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]meth...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed