BDBM276741 US10071991, Compound (I-M2)::US10800764, Compound (I-M2)::US11214566, Compound (I-M2)::US9611259, Compound (I-M2)

SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C1)C(O)=O

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 276741   

TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276741(US10071991, Compound (I-M2) | US10800764, Compound...)
Affinity DataIC50:  11nMpH: 7.0 T: 2°CAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276741(US10071991, Compound (I-M2) | US10800764, Compound...)
Affinity DataIC50:  11nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276741(US10071991, Compound (I-M2) | US10800764, Compound...)
Affinity DataIC50:  11nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276741(US10071991, Compound (I-M2) | US10800764, Compound...)
Affinity DataIC50:  11nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent