BDBM27773 N-(2-amino-5-phenylphenyl)-4-{1,8-diazaspiro[4.5]decan-8-ylmethyl}benzamide::biphenyl diamine analogue, 21

SMILES Nc1ccc(cc1NC(=O)c1ccc(CN2CCC3(CCCN3)CC2)cc1)-c1ccccc1

InChI Key InChIKey=LZBKXQAVFZXXKI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27773   

TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM27773(N-(2-amino-5-phenylphenyl)-4-{1,8-diazaspiro[4.5]d...)
Affinity DataIC50:  8nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM27773(N-(2-amino-5-phenylphenyl)-4-{1,8-diazaspiro[4.5]d...)
Affinity DataIC50:  1.65E+4nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed