BDBM27849 3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyran-2-carboxamide::hydroxypyrone amide, 1a

SMILES Oc1c(occc1=O)C(=O)NCc1ccc(cc1)-c1ccccc1

InChI Key InChIKey=PHBHELQPDZPJEY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 27849   

TargetLethal factor(Bacillus anthracis)
Howard Hughes Medical Institute

LigandPNGBDBM27849(3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyra...)
Affinity DataIC50: >1.00E+5nMpH: 7.0 T: 2°CAssay Description:Fluorescence peptide cleavage assay was performed in a 96-well plate. Each reaction contained fluorogenic peptide substrate, LF, and small-molecule i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM27849(3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyra...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrilysin(Homo sapiens (Human))TBA
LigandPNGBDBM27849(3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyra...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))TBA
LigandPNGBDBM27849(3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyra...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))TBA
LigandPNGBDBM27849(3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyra...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM27849(3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyra...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))TBA
LigandPNGBDBM27849(3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyra...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))TBA
LigandPNGBDBM27849(3-hydroxy-4-oxo-N-[(4-phenylphenyl)methyl]-4H-pyra...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In DepthDetails PubMed