BDBM278841 N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)- or (1R,4R)- 2,5-diazabicyclo[2.2.2] oct-2-yl]thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 20

SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2C[C@H]3CC[C@@H]2CN3)c(Br)n1

InChI Key InChIKey=VFSFIEOIWVINSK-DHTOPLTISA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278841   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278841(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)-...)
Affinity DataIC50:  19nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent