BDBM278853 4-{8-amino-3- [(6S,8aR)-6-methyl-3- oxohexahydro[1,3] oxazolo[3,4-a]pyridin- 6-yl]limidazo[1,5-a] pyrazin-1-yl}-3- ethoxy-N-[4- (trifluoromethyl) pyridin-2-yl] benzamide::US10040805, Example 1

SMILES CCOc1cc(ccc1-c1nc(n2ccnc(N)c12)[C@@]1(C)CC[C@@H]2COC(=O)N2C1)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key InChIKey=HZBFBSZOVNDXHC-WRHNGFHOSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278853   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278853(4-{8-amino-3- [(6S,8aR)-6-methyl-3- oxohexahydro[1...)
Affinity DataIC50:  0.610nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent