BDBM278897 2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(2-(trifluoromethyl) thiophen-3-yl] thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 76

SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccsc3C(F)(F)F)c2n1

InChI Key InChIKey=QSXNLXJFJHAJDY-VZXYPILPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278897   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278897(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(2-(trif...)
Affinity DataIC50:  12nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent