BDBM278914 2-[(3S)- or (3R)- azepan-3- ylamino]-N-(2- cyanophenyl)- thieno[2,3-b]- pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 94

SMILES OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(N[C@@H]3CCCCNC3)nc12

InChI Key InChIKey=KEILVEJHAHKBIS-PFEQFJNWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278914   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278914(2-[(3S)- or (3R)- azepan-3- ylamino]-N-(2- cyanoph...)
Affinity DataIC50:  9nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent