BDBM278942 4-[8-amino-3-(2,7- dimethyl-1- oxooctahydro-1H- pyrido[1,2-c] pyrimidin-7- yl)imidazo[1,5-a] pyrazin-1-yl}-3- ethoxy-N-[4- (trifluoromethyl) pyridin-2-yl] benzamide::US10040805, Example 12::US10040805, Example 13

SMILES CCOc1cc(ccc1-c1nc(n2ccnc(N)c12)C1(C)CCC2CCN(C)C(=O)N2C1)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key InChIKey=IPKWFJWKRLRNPZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278942   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278942(4-[8-amino-3-(2,7- dimethyl-1- oxooctahydro-1H- py...)
Affinity DataIC50:  10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278942(4-[8-amino-3-(2,7- dimethyl-1- oxooctahydro-1H- py...)
Affinity DataIC50:  411nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent